David Julius keynote speaker
- Determining the Molecular Basis of Somatosensation - How We Sense Heat, Cold and Pain
- Natural Products as Probes of the Pain Pathway: From Physiology to Atomic Structure
David Julius, PhD, is professor and chair of the Department of Physiology at UC San Francisco and holds the Morris Herzstein Chair in Molecular Biology and Medicine.
He is a member of the National Academy of Sciences and the American Academy of Arts and Science and has won numerous honors and awards. Those include the UCSF Medal by the University of California, San Francisco (2022), Nobel Prize in Physiology or Medicine (2021), the Kavli Prize in Neuroscience (2020), Breakthrough Prize in Life Sciences (2019), the Canada Gairdner International Award (2017), the Dr. Paul Janssen Award for Biomedical Research (2013), the Shaw Prize (2010), the Passano Award (2010), the Prince of Asturias Award for Technical and Scientific Research (2010), the Scolnick Prize from the McGovern Institute for Brain Research at MIT (2007), the Unilever Science Prize (2007) and the Klaus Joachim Zülch Neuroscience Prize (2006).
A major focus of his work has been to identify and understand molecular mechanisms involved in our senses of touch and pain. His group has exploited the properties of natural products to discover a family of temperature-sensitive ion channel receptors that enable sensory nerve fibers to detect hot or cold temperatures.
These same channels, known as TRP (pronounced “trip”) channels, also respond to chemical stimuli that evoke sensations of heat or cold. The TRPV1 receptor, for example, responds to either warm temperatures or to capsaicin, the compound that gives chili peppers their “heat.” Likewise, the TRPM8 receptor responds to either cool temperatures or menthol. TRP receptors are of great clinical interest, because they are abundantly expressed in pain pathways, and pharmaceutical companies are working to find TRP-related compounds that may offer pain control without the side effects or addictive potential of opioid drugs.
In 2013, Julius and UCSF colleague Yifan Cheng, PhD, used electron microscopy to determine the structure of the TRPV1 receptor at near-atomic resolution. In 2015, Julius and Cheng used to same techniques to determine the structure of TRPA1, the so-called “wasabi receptor.”
Julius is married to Holly Ingraham, PhD, a Professor of Physiology at UCSF. Their son is Philip Julius.
Julius serves on the Board of Directors of The McKnight Endowment Fund for Neuroscience and is a member of the Scientific Advisory Board of the Pew Scholars Program in Biomedical Sciences. He served on the Scientific Advisory Committee of the Damon Runyon Cancer Research Foundation.
